骨髓增生异常综合征患者β2-MG 和LDH检测的临床价值

doi:10.3969/j.issn.1004-616x.2012.04.015

›› 2012, Vol. 24 ›› Issue (4): 302-304.doi: 10.3969/j.issn.1004-616x.2012.04.015

骨髓增生异常综合征患者β2-MG 和LDH检测的临床价值

张冬清;林静华;周焕槟;王雪华;焦晓阳

( 汕头大学医学院第一附属医院检验科，广东汕头 515041 )

收稿日期:2012-03-02 修回日期:2012-05-16 出版日期:2012-07-30 发布日期:2012-07-30
通讯作者: 张冬清

Clinical value of β2-MG and LDH determination in the patients with myelodysplastic syndrome

ZHANG Dong-qing;LIN Jing-hua;ZHOU Huan-bin;WANG Xue-hua;JIAO Xiao-yang

(Department of Clinical Laboratory，the First Affiliated Hospital，Shantou University Medical College，Shantou 515041，Guangdong，China)

Received:2012-03-02 Revised:2012-05-16 Online:2012-07-30 Published:2012-07-30
Contact: ZHANG Dong-qing

摘要/Abstract

摘要： 目的：探讨骨髓增生异常综合征(myelodysplastic syndrome，MDS)患者血清β2-微球蛋白(β2-microglobulin，β2-MG)和乳酸脱氢酶(lactic dehydrogenase，LDH)检测的临床价值。方法：采用放射免疫法测定血清β2-MG，速率法检测LDH，比较两者在30例健康体检者和45例不同亚型MDS患者中的水平，并对两者均增高和均正常的MDS患者进行生存分析。结果：各组MDS患者血清β2-MG水平均明显高于正常对照组(P＜0.01)，其中难治性贫血伴原始细胞过多-II (refractory anemia with excessive blasts II， RAEB-II)组明显高于难治性贫血(refractory anemia，RA)、难治性血细胞减少伴有多系发育异常(refractory cytopenia with multilineage dysplasia，RCMD)和难治性贫血伴原始细胞过多-I(refractory anemia with excessive blasts I，RAEB-I)组，差异均有统计学意义(P均＜0.01)；RAEB-I、RAEB-II组血清LDH水平明显高于RA、RCMD组(P＜0.01)；血清LDH、β2-MG均增高的患者中位生存期明显短于两者均正常者(P<0.01)。结论：联合检测血清β2-MG和LDH水平，对于MDS的诊断、分型及预后分析具有重要的临床价值。

关键词: 骨髓增生异常综合征, β2－微球蛋白, 乳酸脱氢酶, 中位生存期

Abstract: OBJECTIVE: To explore the clinical value of the determination of serum β2-microglobulin(β2-MG) and lactic dehydrogenase(LDH) in patients with myelodysplastic syndrome (MDS). METHODS： Serum β2-MG was determined by radioimmunoassay. Serum LDH was detected by velocity method. The levels of β2-MG and LDH were compared between 30 healthy people and 45 patients with different types of MDS groups. The survival analysis of MDS patients with high and normal level of β2-MG and LDH was made and compared. RESULTS：The levels of β2-MG in all of MDS groups were significantly higher than that in control group (P<0.01). β2-MG in RAEB-II group were significantly higher than that in RA，RCMD and RAEB-I group(P<0.01). The levels of LDH in RAEB-I，RAEB-II groups was significantly higher than that in RA and RCMD groups (P<0.01). Median survival time of the patients with high levels of LDH andβ2-MG was significantly shorter than that of the patients with normal LDH andβ2-MG (P<0.01). CONCLUSION：Combined determination of the levels of serum β2-MG and LDH could confer important clinical significance in the diagnosis，classification and prognosis of MDS .

Key words: myelodysplastic syndrome, β2-microglobulin, lactic dehydrogenase, median survival time

张冬清;林静华;周焕槟;王雪华;焦晓阳. 骨髓增生异常综合征患者β2-MG 和LDH检测的临床价值[J]. , 2012, 24(4): 302-304.

ZHANG Dong-qing;LIN Jing-hua;ZHOU Huan-bin;WANG Xue-hua;JIAO Xiao-yang. Clinical value of β2-MG and LDH determination in the patients with myelodysplastic syndrome[J]. , 2012, 24(4): 302-304.

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骨髓增生异常综合征患者β2-MG 和LDH检测的临床价值

Clinical value of β2-MG and LDH determination in the patients with myelodysplastic syndrome

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